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Newest Articles
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Tobiloba E. Oni, Giulia Biffi, Lindsey A. Baker, Yuan Hao, Claudia Tonelli, Tim D.D. Somerville, Astrid Deschênes, Pascal Belleau, Chang-il Hwang, Francisco J. Sánchez-Rivera, Hilary Cox, Erin Brosnan, Abhishek Doshi, Rebecca P. Lumia, Kimia Khaledi, Youngkyu Park, Lloyd C. Trotman, Scott W. Lowe, Alexander Krasnitz, Christopher R. Vakoc, David A. Tuveson
Uncovering mechanisms that drive pancreatic cancer could lead to effective therapies for this lethal disease. This study reveals how pancreatic cancer cells hyperactivate a pathway to sustain their proliferation. Inhibiting this pathway affects cancer cells, but not normal cells, highlighting a new therapeutic opportunity.
Article
Verónica Delgado-Benito, Maria Berruezo-Llacuna, Robert Altwasser, Wiebke Winkler, Devakumar Sundaravinayagam, Sandhya Balasubramanian, Marieta Caganova, Robin Graf, Ali Rahjouei, Marie-Thérèse Henke, Madlen Driesner, Lisa Keller, Alessandro Prigione, Martin Janz, Altuna Akalin, Michela Di Virgilio
Delgado-Benito et al. identify the protein Pdap1 as a regulator of mature B cell homeostasis. Pdap1 protects mature B cells against chronic induction of the integrated stress response and promotes both their survival and antibody gene diversification by CSR and SHM.
Article
Antony B. Holmes, Clarissa Corinaldesi, Qiong Shen, Rahul Kumar, Nicolo Compagno, Zhong Wang, Mor Nitzan, Eli Grunstein, Laura Pasqualucci, Riccardo Dalla-Favera, Katia Basso
Single-cell transcriptomic analysis of germinal center B cells identifies multiple linked populations, most of which represent cell of origin of lymphomas. The newly identified cell of origin of diffuse large B cell lymphoma informs on novel prognostic subgroups.
Article
Kayan Tam, Keenan A. Lacey, Joseph C. Devlin, Maryaline Coffre, Alexis Sommerfield, Rita Chan, Aidan O’Malley, Sergei B. Koralov, P’ng Loke, Victor J. Torres
Staphylococcus aureus secretes pore-forming leukocidins that kill leukocytes as part of the bacterium’s evasion strategy. Leukocidin-based vaccination results in toxin-neutralizing antibodies and toxin-specific CD4 lymphocytes that block the toxins and boost host-mediated antimicrobial responses to protect mice from bloodstream infection.
Brief Definitive Report
Laura J. Pallett, Alice R. Burton, Oliver E. Amin, Sergio Rodriguez-Tajes, Amit A. Patel, Nekisa Zakeri, Anna Jeffery-Smith, Leo Swadling, Nathalie M. Schmidt, Anna Baiges, Amir Gander, Dominic Yu, David Nasralla, Farid Froghi, Satheesh Iype, Brian R. Davidson, Douglas Thorburn, Simon Yona, Xavier Forns, Mala K. Maini
Pallett et al. identify mononuclear phagocyte and T cell subsets able to reside in the human liver for over a decade, probing their retention and replenishment using HLA-mismatched allografts and hepatic venous sampling.
Article
Xin Li, Liying Gong, Alexandre P. Meli, Danielle Karo-Atar, Weili Sun, Yongrui Zou, Irah L. King, Hua Gu
Antigen uptake and presentation by naive and germinal center (GC) B cells are different, with the former expressing even low-affinity BCRs efficiently capture and present sufficient antigen to T cells, whereas the latter do so more efficiently after acquiring high-affinity BCRs. We show here that antigen uptake and ...
Article
Pei Xuan Lee, Donald Heng Rong Ting, Clement Peng Hee Boey, Eunice Tze Xin Tan, Janice Zuo Hui Chia, Fakhriedzwan Idris, Yukei Oo, Li Ching Ong, Yen Leong Chua, Chanditha Hapuarachchi, Lee Ching Ng, Sylvie Alonso
Lee et al. show that circulating NS1 protein does not contribute to dengue pathogenesis in mice infected with highly virulent DENV2 strains. Instead, structural prME region is found to play a critical role in the in vivo fitness and virulence of these strains.

Related Articles from Rockefeller University Press

Current Issue
Volume 217,
Issue 7,
July 6, 2020
Reviews & Opinions
Insights
Sannula Kesavardhana, Thirumala-Devi Kanneganti
Deciphering ZBP1 activation and its role in sterile or viral-induced cell death.
People & Ideas
Stephanie Houston
Siamon Gordon: A half-century fascination with macrophages
Viewpoint
Betty Diamond
Betty Diamond discusses the potential contribution of the renin–angiotensin system to the pathogenies of COVID-19.

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