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Newest Articles
Yu-Yang Jiang, Wolfgang Maier, Uzoamaka N. Chukka, Michael Choromanski, Chinkyu Lee, Ewa Joachimiak, Dorota Wloga, Wayland Yeung, Natarajan Kannan, Joseph Frankel, Jacek Gaertig
Jiang and colleagues investigate how locations of sites of organelle assembly are determined during cell division in the ciliate Tetrahymena thermophila. They find that correct placement of new organelles involves antagonistic influences of a cyclin E and a Hippo/Mst kinase.
Kostika Sofroni, Hirotomo Takatsuka, Chao Yang, Nico Dissmeyer, Shinichiro Komaki, Yuki Hamamura, Lev Böttger, Masaaki Umeda, Arp Schnittger
CDKA;1, the Arabidopsis orthologue of Cdk1 and Cdk2, controls microtubule organization in meiosis. Sofroni et al. find that reducing CDKA;1 activity converts simultaneous cytokinesis—the separation of all four meiotic products concomitantly—into two successive cytokineses after the first and second meiotic divisions, as found in many crop species.
Kyle Begovich, Anthony Q. Vu, Gene Yeo, James E. Wilhelm
Begovich et al. identify 17 metabolic enzymes that are stress-specific components of yeast stress granules (SGs). The product of one of these enzymes, AdoMet, is an evolutionarily conserved regulator of SG assembly and blocks the recruitment of pathogenic TDP-43 into SGs in ALS models, highlighting its therapeutic potential.
Kwang Woo Ko, Jeffrey Milbrandt, Aaron DiAntonio
Ko et al. demonstrate that SARM1 is required for loss of axons and neurons in a neuroinflammatory model of glaucoma. Neuroinflammatory signaling induces an axonal necroptosis that triggers SARM1-dependent axon degeneration. These findings delineate unexpected molecular and functional relationships among neuroinflammation, necroptosis, and axon degeneration.
Joseph Dopie, Michael J. Sweredoski, Annie Moradian, Andrew S. Belmont
Dopie et al. apply TSA-MS ratio, an approach that compares the abundance of proteins in nuclear speckles with centromeres to reduce nonspecific background, and show that MFAP1 levels modulate nuclear speckle size and MFAP1 is recruited early to reforming nuclear speckles after mitosis.
Nadia Efimova, Changsong Yang, Jonathan X. Chia, Ning Li, Christopher J. Lengner, Kristi L. Neufeld, Tatyana M. Svitkina
Efimova et al. show that adenomatous polyposis coli (APC) at microtubule tips triggers assembly of a branched actin network when the microtubule hits the plasma membrane in neuronal growth cones. These findings uncover a new mechanism of microtubule-dependent cell navigation.
Maria Chiara Raso, Nikola Djoric, Franziska Walser, Sandra Hess, Fabian Marc Schmid, Sibylle Burger, Klaus-Peter Knobeloch, Lorenza Penengo
Raso et al. find that high levels of interferon-stimulated gene 15 (ISG15), which is very frequent in cancer and robustly induced by pathogen infection, accelerate DNA replication fork progression, impacting genome stability and response to chemotherapy.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 7,
July 6, 2020
Reviews & Opinions
Jack Houston, Pablo Lara-Gonzalez, Arshad Desai
Houston et al. synthesize recent work analyzing Mad1–cyclin B1 complex function in mitosis.
Michelle Grace Acoba, Nanami Senoo, Steven M. Claypool
In this review, Acoba et al. discuss the surprisingly complicated mechanisms, regulation, and functions of mitochondrial membrane building.
Nobuo N. Noda, Zheng Wang, Hong Zhang
Zhang and colleagues summarize phase separation and transition in the assembly of autophagosome formation sites and triage of protein condensates for degradation.

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