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Historical collection: Cell death

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Yui Tomioka, Tetsuya Kotani, Hiromi Kirisako, Yu Oikawa, Yayoi Kimura, Hisashi Hirano, Yoshinori Ohsumi, Hitoshi Nakatogawa
Autophagy selectively degrades a wide range of cellular components to regulate cellular functions or maintain cellular homeostasis. Tomioka et al. reveal that the nuclear pore complex and nucleoporins are degraded by selective autophagy upon inactivation of Tor kinase complex 1 in Saccharomyces cerevisiae.
Article
Dorotea Fracchiolla, Chunmei Chang, James H. Hurley, Sascha Martens
Autophagy requires the synthesis of PI(3)P and the conjugation of LC3 to the phagophore membrane. We reconstituted these two reactions and their coupling by WIPI2 and showed that positive feedback between PI3KC3-C1 and WIPI2 leads to rapid LC3 lipidation by the ATG16L1 complex.
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Marisa D. Ruehle, Alexander J. Stemm-Wolf, Chad G. Pearson
Sas4 is a conserved basal body assembly protein. Here, Ruehle et al. describe a previously unknown link between basal bodies and the control of cell division by Hippo signaling molecules that depends on Sas4.
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Bing Liu, Muhammad Younus, Suhua Sun, Yiman Li, Yuan Wang, Xi Wu, Xiaoxuan Sun, Shujiang Shang, Changhe Wang, Changhe Wang, Michael X. Zhu, Michael X. Zhu, Zhuan Zhou, Zhuan Zhou
TRPA1 is a nonselective cation channel implicated in thermosensation and inflammatory pain. Liu et al. validated that TRPA1 activation not only triggers Ca2+ influx through the plasma membrane, but also elicits Ca2+ release from endolysosomes, which directly triggers vesicle exocytosis and contributes to nocifensive sensation.
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Alexandra F. Long, Pooja Suresh, Sophie Dumont
To segregate chromosomes, the mammalian spindle must generate and respond to force. How it does so remains poorly understood. Pulling on the spindle using microneedles, Long et al. show that it can locally dissipate sustained force by regulating microtubule dynamics and breakage, thereby preserving global spindle structure.
Letter
Lisa A. Gebhardt, Tetyana I. Kichko, Michael J.M. Fischer, Peter W. Reeh
Refutation of TRPA1-mediated lysosomal calcium release in sensory neurons, emphasizing the requirement and influx of extracellular calcium through TRPA1 for activation.
Article
Paurav B. Desai, Michael W. Stuck, Bo Lv, Gregory J. Pazour
Hedgehog signaling involves the dynamic movement of receptors and effectors in and out of cilia. Desai et al. found that the dynamics of Smo are regulated by ubiquitination, which modulates its interaction with the intraflagellar transport system to control ciliary levels of this receptor.

Related Articles from Rockefeller University Press

Current Issue
Volume 219,
Issue 5,
May 4, 2020
Reviews & Opinions
Spotlight
Levi Ali, Cole M. Haynes
Ali and Haynes preview recent work from Liu et al. that provides new insight into the connection between mitochondrial dynamics, mitochondrial translation, and organismal longevity.
Viewpoint | Reproducibility
Rob C.I. Wüst, Riekelt H. Houtkooper, Johan Auwerx
This Reproducibility Viewpoint discusses confounding factors of Tet-On/Tet-Off and Cre/loxP systems, including doxycycline-induced microbiome alterations, mitochondrial dysfunction, and tamoxifen-induced toxicity.
Spotlight
Joyce C.M. Meiring, Anna Akhmanova
Meiring and Akhmanova preview work from Kopf et al. that shows that microtubules act to prevent cell rupture during protrusion extension in dendritic cells via regulation of actomyosin contractility.

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